Proton pump inhibitors, or PPIs, are used for prevention of gastric reflux. Common brands are Prilosec and Prevacid. These popular medications may raise the chances for having a heart attack. This came from research which included a study of close to three million people. Prior studies showed a connection with PPI use by heart disease patients. Likely, this was connected to the drug interactions between PPI use and clopidogrel, which is a drug which is prescribed post a heart attack. This new study, as reported in New York Time – Well, takes a look at the risk for heart attacks with healthy people.
Using data mining, a mathematical data analysis, PPIs were studied over time. As long ago as the year 2000, there was evidence that they increased the chances for heart attacks, which scared Gianfrancesco Genoso a little. Now that medical records are electronic, there is a greater chance for more analysis. There was no correlation between heart attack with other gastric reflux medications, which are H2 blockers, such as Zantac, Pepcid, and Tagamet. Specifically, PPIs tends to increase the chances of inflammation and blood clots. One reason to consider is that one of the study limitations is that PPI use was factored in with a less healthy patient population. They may already be prone to heart disease, based on other health issues.